AMBLEMINAE Rafinesque, 1820
Rafinesque, 1820, Ann. Gén. Sci. Phys. 5 (13): 310 [as ‘Amblemidia, Les Amblémides’].
Deshayes, 1830, Enc. Méth. 2 (Première partie): 18 [as ‘Ablemidiæ’ [sic] ].
Modell, 1942, Arch. Moll. 74(5/6): 180.
Type genus: Amblema Rafinesque, 1820 = Amblema

LAMPSILINAE Ihering, 1901
Ihering, 1901, Nautilus 15(4): 53.
Ortmann, 1910, Nautilus 23: 118.
Ortmann, 1912, Ann. Carnegie Mus. 8: 224.
Type genus: Lampsilis Rafinesque, 1820 = Lampsilis

QUADRULINAE Ihering, 1901
Ihering, 1901, Nautilus 15(5): 53 [as ‘Quadrulinæ’].
Haas, 1929, Senckenbergiana 11: .
Type genus: Quadrula Rafinesque, 1820 = Quadrula

PLEUROBEMINAE Hannibal, 1912
Hannibal, 1912, Proc. Malac. Soc. London 10(2): 119.
Modell, 1942, Arch. Moll. 74(5/6): 179.
Type genus: Pleurobema Rafinesque, 1819 = Pleurobema

PROPTERINAE Hannibal, 1912
Hannibal, 1912, Proc. Malac. Soc. London 10(2): 119.
Type genus: Proptera Rafinesque, 1819 = Potamilus

ELLIPTIONINAE Modell, 1942
Modell, 1942, Arch. Moll. 74(5/6): 178, 180.
Modell, 1943, Arch. Moll. 75: 110.
Modell, 1964, Arch. Moll. 93: 88.
Type genus: Elliptio Rafinesque, 1819 = Elliptio

CYPROGENIINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Cyprogenia Agassiz, 1852 = Cyprogenia

DROMINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Dromus Simpson, 1900 = Dromus

FRIERSONIINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Friersonia Ortmann, 1912 = Friersonia

GLEBULINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Glebula Conrad, 1853 = Glebula

MEDIONIDINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Medionidus Simpson, 1900 = Medionidus

MEGALONAIADINAE Heard & Guckert, 1970
Heard & Guckert, 1970, Malacologia 10: 338.
Type genus: Megalonaias Utterback, 1915 = Megalonaias

PILAEINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
(name corrected to Pileinae Starobogatov, 1970)
Type genus: Pilea Simpson, 1900 = Epioblasma

PILEINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287 [as ‘Pilaeini’].
(correct name for Pilaeinae Starobogatov, 1970)
Type genus: Pilea Simpson, 1900 = Epioblasma

POPENAIADINAE Heard & Guckert, 1970
Heard & Guckert, 1970, Malacologia 10: 339.
Type genus: Popenaias Frierson, 1927 = Popenaias

PTYCHOBRANCHINAE Starobogatov, 1970
Starobogatov, 1970, Fauna Moll. Continent.: 70, 287.
Type genus: Ptychobranchus Simpson, 1900 = Ptychobranchus

POPENAIDINAE Graf & Cummings, 2021
Graf & Cummings, 2021, J. Moll. Studies 87(1): 6.
(error for Popenaiadinae Heard & Guckert, 1970)
Type genus: Popenaias Frierson, 1927 = Popenaias