 genus Epioblasma Rafinesque, 1831: 28 Recent species. 15 generic synonyms | 29 valid species | cladomics Distribution: North America. |
 genus Lampsilis Rafinesque, 1820: 26 Recent species. 7 generic synonyms | 34 valid species | cladomics Distribution: North America. |
 genus Potamilus Rafinesque, 1818: 10 Recent species. 25 generic synonyms | 11 valid species | cladomics Distribution: East Asia, North America. |
 genus Actinonaias Crosse & Fischer, 1894: 7 Recent species. 4 generic synonyms | 10 valid species | cladomics Distribution: Central America. |
 genus Cambarunio Watters, 2018: 7 Recent species. 1 generic synonym | 7 valid species | cladomics Distribution: North America. |
 genus Obovaria Rafinesque, 1819: 7 Recent species. 5 generic synonyms | 7 valid species | cladomics Distribution: North America. |
 genus Toxolasma Rafinesque, 1831: 7 Recent species. 4 generic synonyms | 7 valid species | cladomics Distribution: North America. |
 genus Disconaias Crosse & Fischer, 1894: 6 Recent species. 2 generic synonyms | 6 valid species | cladomics Distribution: Central America, North America. |
 genus Medionidus Simpson, 1900: 6 Recent species. 2 generic synonyms | 7 valid species | cladomics Distribution: North America. |
 genus Ptychobranchus Simpson, 1900: 6 Recent species. 3 generic synonyms | 8 valid species | cladomics Distribution: North America. |
 genus Leaunio Watters, 2018: 5 Recent species. 1 generic synonym | 5 valid species | cladomics Distribution: North America. |
 genus Venustaconcha Frierson, 1927: 5 Recent species. 2 generic synonyms | 5 valid species | cladomics Distribution: North America. |
 genus Cyrtonaias Crosse & Fischer, 1894: 4 Recent species. 3 generic synonyms | 4 valid species | cladomics Distribution: Central America, North America. |
 genus Hamiota Roe & Hartfield, 2005: 4 Recent species. 1 generic synonym | 4 valid species | cladomics Distribution: North America. |
 genus Sagittunio Watters, 2018: 4 Recent species. 1 generic synonym | 4 valid species | cladomics Distribution: North America. |
 genus Truncilla Rafinesque, 1819: 4 Recent species. 4 generic synonyms | 4 valid species | cladomics Distribution: North America. |
 genus Villosa Frierson, 1927: 4 Recent species. 1 generic synonym | 4 valid species | cladomics Distribution: North America. |
 genus Arotonaias Martens, 1900: 3 Recent species. 3 generic synonyms | 3 valid species | cladomics Distribution: Central America. |
 genus Delphinonaias Crosse & Fischer, 1894: 3 Recent species. 3 generic synonyms | 3 valid species | cladomics Distribution: Central America. |
 genus Cyprogenia Agassiz, 1852: 2 Recent species. 3 generic synonyms | 2 valid species | cladomics Distribution: North America. |
 genus Ortmanniana Frierson, 1927: 2 Recent species. 1 generic synonym | 2 valid species | cladomics Distribution: North America. |
 genus Pachynaias Crosse & Fischer, 1894: 2 Recent species. 2 generic synonyms | 2 valid species | cladomics Distribution: Central America. |
 genus Atlanticoncha Smith, Pfeiffer & Johnson, 2020: 1 Recent species. 1 generic synonym | 1 valid species | cladomics Distribution: North America. |
 genus Dromus Simpson, 1900: 1 Recent species. 3 generic synonyms | 1 valid species | cladomics Distribution: North America. |
 genus Ellipsaria Rafinesque, 1820: 1 Recent species. 3 generic synonyms | 1 valid species | cladomics Distribution: North America. |
 genus Friersonia Ortmann, 1912: 1 Recent species. 1 generic synonym | 1 valid species | cladomics Distribution: Central America. |
 genus Glebula Conrad, 1853: 1 Recent species. 1 generic synonym | 1 valid species | cladomics Distribution: North America. |
 genus Lemiox Rafinesque, 1831: 1 Recent species. 2 generic synonyms | 2 valid species | cladomics Distribution: North America. |
 genus Ligumia Swainson, 1840: 1 Recent species. 4 generic synonyms | 9 valid species | cladomics Distribution: North America. |
 genus Obliquaria Rafinesque, 1820: 1 Recent species. 2 generic synonyms | 1 valid species | cladomics Distribution: North America. |
 genus Paetulunio Watters, 2018: 1 Recent species. 2 generic synonyms | 1 valid species | cladomics Distribution: North America. |